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milk thistle depression

Some researchers have suggested milk thistle benefits when treating osteoporosis after menopause, and it's a commonly used supplement in the U.S. But studies on heart benefits have only been done in people with diabetes. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Eur Endocrinol. Milk thistle is often sold as an herbal supplement. Osteoporosis is a disease caused by progressive bone loss. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. Milk thistle may not be safe for everyone. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Subjects were assessed with the National Institute of Mental Health Trichotillomania Severity Scale (primary outcome), the Massachusetts General Hospital Hair Pulling Scale, Clinical Global Impression scale, and measures of depression, anxiety, and psychosocial . and transmitted securely. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. 3 Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Epub 2013 Oct 14. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. Phytother Res. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Milk thistlesupplementscontaining silymarin are commonly sold as teas or in capsule form, but are also available as tablets, soft gels, and liquid extracts. Reflux Risk and Relief View More . Some people have nausea, diarrhea, itching, and bloating. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Milk thistle is a popular herbal remedy that has been used for its therapeutic effects for centuries. Liu HY, Wei HJ, Wu L, Liu SM, Tang YY, Zou W, Wang CY, Zhang P, Tang XQ. In clinical trials, milk thistle appears to be well tolerated in recommended doses. However, few of these claims are supported by solid evidence. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Milk thistle can cause severe allergic reaction and anaphylaxis, a rare but potentially life-threatening allergic reaction. A 2010 review by researchers found that black . Botanicals and their bioactive phytochemicals for women's health. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. And Selenium too. information is beneficial, we may combine your email and website usage information with Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y, Seeff LB, Curto TM, Szabo G, et al. Epub 2023 Mar 4. Can You Get Milk Thistle Naturally From Foods? In reducing oxidative stress, milk thistle is believed to be neuroprotective by helping prevent decline in brain function. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Elsevier; 2021. https://www.clinicalkey.com. This herb (also known as Silybum marianum) is native to the Mediterranean region. This flowering plant can help control blood sugar levels and enhance bone health. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. #1: Milk thistle detoxifies the liver. While the cost of most OCD medications currently available on the market is actually quite reasonable, the common side effects that occur are definitely not. . 2016;5147468. doi:10.1155/2016/5147468. It is not certain whether milk thistle is effective in treating any medical condition. The terms "milk thistle" and "silymarin" are often used interchangeably. Although more research is needed on how it works, milk thistle is thought to reduce damage to the liver caused by free radicals, which are produced when your liver metabolizes toxic substances. https://www.nccih.nih.gov/health/milk-thistle. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Some people may be allergic to milk thistle. In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). The nutritional content varies for each brand, so be sure to . FOIA However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. 2018;8:65-74. doi:10.2147/PTT.S169333. Using different formulations together increases the risk of an overdose. Mastron JK, Siveen KS, Sethi G, Bishayee A.Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. However, this is the only clinical study available. Multiple Myeloma vs. Leukemia: What Are the Differences? For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. In this study, the effect of silibinin on A-induced anxiety/depression-like behaviors in rats was investigated. Well go over the methods that doctors use to determine this and provide a chart, Blessed thistle is an herb with a long history of use for digestive issues and breastfeeding. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Pizzorono JE, et al., eds. Thank you, {{form.email}}, for signing up. Before taking milk thistle, talk to your doctor, pharmacist, or health care professional if you have allergies (especially to plants), have any medical conditions, or if you take other medicines or other herbal/health supplements. health information, we will treat all of that information as protected health privacy practices. World J Gastroenterol. Milk thistle. A double-blind controlled study. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2015;26(5):475486. 2020;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003. Advertising revenue supports our not-for-profit mission. Questions? People with diabetes should use caution. official website and that any information you provide is encrypted Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). Effect of silymarin on chemical, functional, and morphological alterations of the liver. But even if youve figured out how to manage the symptoms and compulsions, the side effects of many FDA-approved OCD medications can introduce a wide swath of issues and side effects. By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. Moreover, its unclear whether milk thistle is well enough absorbed in people to allow adequate amounts to pass through the blood-brain barrier. Studies on cancer cell lines (done in the laboratory) have found that elements in milk thistle: Researchers also are looking at how milk thistle might complement traditional care and treatment in people diagnosed with gastrointestinal cancers. CNS Neurosci Ther. Milk thistle and its antioxidant properties are promising in managing OCD symptoms but it may also be beneficial to explore other herbs for OCD treatment to bolster and round out a supplement regimen. Type 2 Diabetes According to research published in Phytomedicine in 2015, silymarin improved antioxidant capacity in the body and decreased inflammation in adults with type 2 diabetes by beating the placebo in a triple blind trial. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. By using our site, you acknowledge that you have read and understand our. There is a problem with 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Researchers also have found that milk thistle improved insulin resistance, a key part of type 2 diabetes. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This publication is not copyrighted and is in the public domain. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Effects of Silybum marianum (L.) Gaertn. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. If you choose to use milk thistle, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. There are other supplements that work similarly to milk thistle. Accessed Oct. 30, 2020. include protected health information. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). 2014;2014:941085. doi:10.1155/2014/941085. The information and products shown on this website should not be interpreted as a substitute for physician evaluation or treatment. Thus, more studies are needed to determine what dose and length of treatment are needed for specific liver conditions (2, 11, 12). Milk thistle. Milk thistle is generally considered safe when taken by mouth (1, 45). By Brittany Lubeck, RD Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. There is also concern that milk thistle might affect estrogen levels. Call 911 or seek help right away if you experience severe side effects from taking milk thistle. information highlighted below and resubmit the form. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. About curcumin, it isn't usually a problem but if you're on IMAOs you may like to read a bit before taking high doses. The research on milk thistle's use in cancer patients is promising, although more research is needed to determine its benefits. Acne is a chronic inflammatory skin condition. Dupuis ML, Conti F, Maselli A, et al. Therefore, it may be best to avoid milk thistle during these life stages. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010, Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Version: 2.01. Luckily, more and more experts are turning to natural remedies to answer that question and circumvent the litany of side effects. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Consult with a licensed healthcare professional before using any herbal/health supplement. Some people are advised to be cautious when taking milk thistle. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. There is also concern that milk thistle might affect estrogen levels. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Although rare, milk thistle may trigger a number of common and mild side effects. It is primarily considered a cleansing agent and used to block or flush toxins from the body. NCCIH has provided this material for your information. Silymarin is an active component of milk thistle, which is not found in foods. Side effects. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Milk thistle can trigger allergic reactions. People who are allergic to artichokes, kiwi, ragweed, daisies, marigolds, and chrysanthemums are at higher risk. Experts believe silymarin is the primary active ingredient of the herb. In some cases it may be useful in treating these cancers, but studies have yet to fully demonstrate the safety and efficacy of milk thistle use. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Beware that milk thistle can worsen depression, it doesn't act the same on everybody. Epub 2019 Nov 24. Copyright 2017 Elsevier Inc. All rights reserved. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. People sometimes eat the stem and leaves of milk thistle in salads. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). 2012;308(3):274-282. doi:10.1001/jama.2012.8265, Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Some people also call it Mary thistle and holy thistle. Natural Medicines website. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. See additional information. 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin.

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